Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 10/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 8/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.32 |
| ▸ | MERTK | Q12866 | 1/20 | 0.32 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.30 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16690941 | 0.90 | FEN1 (0.43) | FEN1ALOX5APMAPK1MAPK8MAPK10 | |
| SCHEMBL16690765 | 0.89 | FEN1 (0.37) | FEN1ALOX5APMAPK1FLT3TYRO3 | |
| SCHEMBL16679256 | 0.89 | FEN1 (0.37) | FEN1ALOX5APMAPK1FLT3TYRO3 | |
| SCHEMBL16679255 | 0.89 | FEN1 (0.37) | FEN1ALOX5APMAPK1FLT3TYRO3 | |
| SCHEMBL9072420 | 0.82 | FEN1 (0.38) | FEN1ALOX5AP | |
| SCHEMBL19039756 | 0.74 | FEN1 (0.37) | FEN1ALOX5AP | |
| SCHEMBL19053653 | 0.74 | FEN1 (0.35) | FEN1ALOX5AP | |
| SCHEMBL16690766 | 0.74 | FEN1 (0.37) | FEN1ALOX5AP | |
| SCHEMBL16684582 | 0.73 | MAPK1 (0.41) | MAPK1 | |
| SCHEMBL16684540 | 0.73 | MAPK1 (0.41) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3063143-A1 | AMINOHETEROARYL BENZAMIDES AS KINASE INHIBITORS | Novartis AG (CH) | 2016-09-07 | — | — | EP | disclosed |
| WO-2015066188-A1 | AMINOHETEROARYL BENZAMIDES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2015-05-07 | — | — | WO | disclosed |