Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.40 |
| ▸ | SLC18A3 | Q16572 | 4/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 3/20 | 0.31 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12715915 | 0.83 | NOTUM (0.54) | NOTUMSLC6A2SLC6A4SLC18A3SIGMAR1 | |
| SCHEMBL16684820 | 0.80 | SLC6A2 (0.45) | NOTUMSLC6A2SLC6A4HTR2C | |
| SCHEMBL13209332 | 0.76 | NOTUM (0.51) | NOTUMSLC6A2SLC6A4SLC18A3SIGMAR1 | |
| SCHEMBL23666366 | 0.73 | SLC6A2 (0.48) | NOTUMSLC6A2SLC6A4SLC18A3SIGMAR1 | |
| SCHEMBL9917019 | 0.72 | NOTUM (0.60) | NOTUMSLC6A2SLC6A4SLC18A3SIGMAR1 | |
| SCHEMBL31573145 | 0.72 | NOTUM (0.60) | NOTUMSLC6A2SLC6A4SLC18A3SIGMAR1 | |
| SCHEMBL17452502 | 0.70 | AKT1 (0.46) | NOTUMSLC6A2SLC6A4SIGMAR1FFAR1 | |
| SCHEMBL22003919 | 0.70 | NOTUM (0.42) | NOTUMSLC6A2SLC6A4SLC18A3SIGMAR1 | |
| SCHEMBL13518854 | 0.70 | AKT1 (0.47) | NOTUMSLC6A2SLC6A4SLC18A3SIGMAR1 | |
| SCHEMBL13518853 | 0.69 | NOTUM (0.41) | NOTUMSLC6A2SLC6A4SLC18A3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015066344-A1 | 5-HT2C RECEPTOR AGONISTS AND COMPOSITIONS AND METHODS OF USE | ARENA PHARMACEUTICALS, INC. (US) | 2015-05-07 | — | — | WO | disclosed |