Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 4/20 | 0.41 |
| ▸ | LATS1 | O95835 | 6/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CHUK | O15111 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19100555 | 0.82 | MAPK1 (0.53) | MAPK1GSK3BCYP1A2DYRK1ARAB9A | |
| SCHEMBL15081348 | 0.76 | MAPK1 (0.46) | MAPK1GSK3BCYP1A2DYRK1A | |
| SCHEMBL1141943 | 0.75 | MAPK1 (0.48) | MAPK1GSK3BCYP1A2DYRK1A | |
| SCHEMBL3712153 | 0.73 | MAPK1 (0.46) | MAPK1GSK3BCYP1A2DYRK1A | |
| SCHEMBL25945842 | 0.73 | LATS1 (0.42) | MAPK1GSK3BLATS1CYP1A2LATS2 | |
| SCHEMBL13759613 | 0.72 | ATR (0.42) | MAPK1NAMPTCYP17A1RAB9A | |
| SCHEMBL14884375 | 0.72 | JAK1 (0.48) | NAMPTDYRK1A | |
| SCHEMBL15081339 | 0.72 | CDK2 (0.58) | MAPK1GSK3BCYP1A2RAB9A | |
| SCHEMBL18522430 | 0.71 | NAMPT (0.50) | NAMPTCYP17A1LATS1RAB9A | |
| SCHEMBL3361949 | 0.70 | MAPK1 (0.43) | MAPK1CYP17A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2927233-A1 | INHIBITORS OF SEMICARBAZIDE-SENSITIVE AMINE OXIDASE | Proximagen Limited (GB) | 2015-10-07 | — | — | EP | disclosed |
| EP-2547677-B1 | INHIBITORS OF SEMICARBAZIDE-SENSITIVE AMINE OXIDASE | PROXIMAGEN LTD (GB) | 2015-05-06 | — | — | EP | disclosed |