Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 4/20 | 0.48 |
| ▸ | IKBKB | O14920 | 6/20 | 0.43 |
| ▸ | CHUK | O15111 | 5/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | PAK4 | O96013 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | LTK | P29376 | 1/20 | 0.43 |
| ▸ | GRK5 | P34947 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29540441 | 0.90 | AURKB (0.56) | PRKCIIKBKBCHUKAURKBDAPK3 | |
| SCHEMBL98273 | 0.90 | AURKB (0.56) | PRKCIIKBKBCHUKAURKBDAPK3 | |
| SCHEMBL29540628 | 0.87 | PRKCI (0.44) | PRKCIIKBKBCHUKAURKBDAPK3 | |
| SCHEMBL99826 | 0.87 | PRKCI (0.44) | PRKCIIKBKBCHUKAURKBDAPK3 | |
| SCHEMBL99682 | 0.85 | PRKCI (0.49) | PRKCIIKBKBCHUKAURKBDAPK3 | |
| SCHEMBL29541194 | 0.85 | PRKCI (0.49) | PRKCIIKBKBCHUKAURKBDAPK3 | |
| SCHEMBL29540640 | 0.84 | CIT (0.48) | AURKBIGF1RROCK1AURKAINCENP | |
| SCHEMBL98969 | 0.84 | CIT (0.48) | AURKBIGF1RROCK1AURKAINCENP | |
| SCHEMBL29541139 | 0.84 | PRKCI (0.45) | PRKCIIKBKBCHUKAURKBDAPK3 | |
| SCHEMBL99293 | 0.84 | PRKCI (0.45) | PRKCIIKBKBCHUKAURKBDAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2348023-B1 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | INCYTE CORP (US) | 2015-05-06 | — | — | EP | disclosed |