Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.70 |
| ▸ | NPC1 | O15118 | 2/20 | 0.65 |
| ▸ | RAB9A | P51151 | 2/20 | 0.65 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.56 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.50 |
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | DAO | P14920 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | AXL | P30530 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31198184 | 0.84 | HPGD (0.72) | HPGDNPC1RAB9AKCNK3KCNK9 | |
| SCHEMBL27652929 | 0.83 | HPGD (0.76) | HPGDNPC1RAB9AKCNK3KCNK9 | |
| SCHEMBL7715873 | 0.83 | HPGD (0.70) | HPGDNPC1RAB9AKCNK3KCNK9 | |
| SCHEMBL15070509 | 0.83 | HPGD (0.70) | HPGDNPC1RAB9AKCNK3KCNK9 | |
| SCHEMBL6623847 | 0.82 | HPGD (1.00) | HPGDNPC1RAB9AKCNK3KCNK9 | |
| Hydrochloric Acid SCHEMBL27518063 | 0.81 | HPGD (0.68) | HPGDNPC1RAB9AKCNK3KCNK9 | |
| SCHEMBL21114830 | 0.80 | HPGD (0.66) | HPGDNPC1RAB9AKCNK3KCNK9 | |
| SCHEMBL8826894 | 0.79 | NPC1 (0.63) | NPC1RAB9AKMT2AGAAMEN1 | |
| SCHEMBL8537614 | 0.79 | NPC1 (0.63) | NPC1RAB9AKMT2AGAAMEN1 | |
| SCHEMBL18010168 | 0.79 | HPGD (0.64) | HPGDNPC1RAB9AKCNK3KCNK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3290525-B1 | METHOD FOR SCREENING DRUG AND THERAPEUTIC TARGET USED FOR TREATING ALZHEIMER'S DISEASE | JIANGSU NUO BETA PHARMACEUTICAL TECH CO LTD (CN) | 2022-02-23 | — | — | EP | disclosed |
| EP-3290525-A1 | METHOD FOR SCREENING DRUG AND THERAPEUTIC TARGET USED FOR TREATING ALZHEIMER'S DISEASE | Jiangsu Nuo-Beta Pharmaceutical Technology Co., Ltd. (CN) | 2018-03-07 | — | — | EP | disclosed |
| EP-3290514-A1 | APPLICATION OF PI4KIII PROTEIN AND RELATED MEMBRANE PROTEIN COMPLEX IN TREATING ALZHEIMER'S DISEASE | Jiangsu Nuo-Beta Pharmaceutical Technology Co., Ltd. (CN) | 2018-03-07 | — | — | EP | disclosed |
| US-9682931-B2 | Aryloyl(oxy or amino)pentafluorosulfanylbenzene compound, pharmaceutically acceptable salt thereof, and prodrugs thereof | UBE INDUSTRIES, LTD. (JP) | 2017-06-20 | — | — | US | disclosed |
| WO-2015064764-A1 | ARYLOYL(OXY OR AMINO)PENTAFLUOROSULFANYLBENZENE COMPOUND, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND PRODRUGS THEREOF | 宇部興産株式会社 | 2015-05-07 | — | — | WO | disclosed |