SCHEMBL16692875

SCHEMBL16692875

O=C(NC1CCC(N2CCNCC2)CC1)c1n[nH]cc1NC(=O)c1c(F)cccc1F

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK2 P24941 11/20 0.51
CCNA2 P20248 9/20 0.51
CDK1 P06493 6/20 0.51
CCNB1 P14635 6/20 0.51
CCNA1 P78396 2/20 0.51
CDK5 Q00535 3/20 0.42
CCNT1 O60563 2/20 0.42
CDK9 P50750 2/20 0.42
CDK5R1 Q15078 2/20 0.42
DYRK1A Q13627 3/20 0.40
CDK4 P11802 2/20 0.40
CASK O14936 1/20 0.40
CDKL5 O76039 1/20 0.40
CDK14 O94921 1/20 0.40
CCNB2 O95067 1/20 0.40
MAK P20794 1/20 0.40
CDK11B P21127 1/20 0.40
CCND1 P24385 1/20 0.40
CCNE1 P24864 1/20 0.40
CCND3 P30281 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8224133 0.91 CDK2 (0.50) CDK2CCNA2CDK1CCNB1CCNA1
SCHEMBL8262294 0.90 CDK2 (0.46) CDK2CCNA2CDK1CCNB1CCNA1
SCHEMBL1286726 0.90 CDK2 (0.46) CDK2CCNA2CDK1CCNB1CCNA1
SCHEMBL8260214 0.90 CDK2 (0.46) CDK2CCNA2CDK1CCNB1CCNA1
SCHEMBL12000424 0.90 CDK2 (0.46) CDK2CCNA2CDK1CCNB1CCNA1
SCHEMBL8210783 0.90 CDK2 (0.46) CDK2CCNA2CDK1CCNB1CCNA1
SCHEMBL8261139 0.90 CDK2 (0.46) CDK2CCNA2CDK1CCNB1CCNA1
SCHEMBL8260901 0.90 CDK2 (0.46) CDK2CCNA2CDK1CCNB1CCNA1
SCHEMBL12000427 0.89 CDK2 (0.45) CDK2CCNA2CDK1CCNB1CCNA1
SCHEMBL8218857 0.89 CDK2 (0.45) CDK2CCNA2CDK1CCNB1CCNA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2256106-B1 3,4-disubstituted 1H-pyrazole compounds and their use as cyclin dependent kinases (CDK) and glycogen synthase kinase-3 (GSK-3) modulators ASTEX THERAPEUTICS LTD (GB) 2015-05-06 EP disclosed