Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 20/20 | 0.56 |
| ▸ | HSP90AB1 | P08238 | 20/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11903660 | 0.98 | HSP90AA1 (0.55) | HSP90AA1HSP90AB1 | |
| SCHEMBL3527163 | 0.91 | HSP90AA1 (0.69) | HSP90AA1HSP90AB1 | |
| SCHEMBL18203248 | 0.89 | HSP90AA1 (0.55) | HSP90AA1HSP90AB1 | |
| SCHEMBL18203503 | 0.89 | HSP90AA1 (0.55) | HSP90AA1HSP90AB1 | |
| SCHEMBL3745445 | 0.89 | HSP90AA1 (0.64) | HSP90AA1HSP90AB1 | |
| SCHEMBL18203300 | 0.88 | HSP90AA1 (0.59) | HSP90AA1HSP90AB1 | |
| SCHEMBL18203510 | 0.88 | HSP90AA1 (0.56) | HSP90AA1HSP90AB1 | |
| SCHEMBL11909327 | 0.88 | HSP90AA1 (0.54) | HSP90AA1HSP90AB1 | |
| SCHEMBL3115851 | 0.86 | HSP90AA1 (0.70) | HSP90AA1HSP90AB1 | |
| SCHEMBL18203299 | 0.86 | HSP90AA1 (0.52) | HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3091019-B1 | PURINE DERIVATIVES USEFUL AS HSP90 INHIBITORS | SLOAN KETTERING INST CANCER RES (US) | 2019-04-03 | — | — | EP | disclosed |
| EP-3091019-A2 | PURINE DERIVATIVES USEFUL AS HSP90 INHIBITORS | Sloan Kettering Institute For Cancer Research (US) | 2016-11-09 | — | — | EP | disclosed |
| WO-2011044394-A1 | PURINE DERIVATIVES USEFUL AS HSP90 INHIBITORS | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2011-04-14 | — | — | WO | disclosed |