SCHEMBL16695012

SCHEMBL16695012

CC(C)(C)OC(=O)NCC1CCN(c2c(Br)cncc2[N+](=O)[O-])CC1

nearest known ligand 0.47

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ CKS1B P61024 1/20 0.47
▸ SKP1 P63208 1/20 0.47
▸ SKP2 Q13309 1/20 0.47
▸ ACACB O00763 10/20 0.41
▸ ACACA Q13085 9/20 0.41
▸ DRD2 P14416 2/20 0.40
▸ SUV39H2 Q9H5I1 2/20 0.38
▸ CACNA1I Q9P0X4 1/20 0.38
▸ KDM4E B2RXH2 1/20 0.37
▸ PKM P14618 1/20 0.37
▸ MAPT P10636 1/20 0.36
▸ TDP1 Q9NUW8 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16608976 0.85 CKS1B (0.45) CKS1BSKP1SKP2DRD2SUV39H2
SCHEMBL16694774 0.84 CKS1B (0.45) CKS1BSKP1SKP2ACACBACACA
SCHEMBL14659830 0.80 CKS1B (0.49) CKS1BSKP1SKP2ACACBACACA
SCHEMBL12068759 0.78 MAPT (0.47) CKS1BSKP1SKP2ACACBACACA
SCHEMBL16608958 0.78 RET (0.41) CKS1BSKP1SKP2DRD2SUV39H2
SCHEMBL16608907 0.78 RET (0.41) CKS1BSKP1SKP2DRD2SUV39H2
SCHEMBL16608911 0.78 RET (0.41) CKS1BSKP1SKP2DRD2SUV39H2
SCHEMBL16608964 0.78 RET (0.41) CKS1BSKP1SKP2DRD2SUV39H2
SCHEMBL3436185 0.78 CKS1B (0.54) CKS1BSKP1SKP2ACACBACACA
SCHEMBL12068465 0.78 CKS1B (0.48) CKS1BSKP1SKP2ACACBACACA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180194775-A1 COMPOUND HAVING AGONISTIC ACTIVITY ON SOMATOSTATIN RECEPTOR, AND USE THEREOF FOR MEDICAL PURPOSES ONO PHARMACEUTICAL CO., LTD. (JP) 2018-07-12 — — US disclosed
US-9975904-B2 Compound having agonistic activity on somatostatin receptor, and use thereof for medical purposes ONO PHARMACEUTICAL CO., LTD. (JP) 2018-05-22 — — US disclosed
US-20170183359-A1 COMPOUND HAVING AGONISTIC ACTIVITY ON SOMATOSTATIN RECEPTOR, AND USE THEREOF FOR MEDICAL PURPOSES ONO PHARMACEUTICAL CO., LTD. (JP) 2017-06-29 — — US disclosed
US-9630976-B2 Compound having agonistic activity on somatostatin receptor, and use thereof for medical purposes ONO PHARMACEUTICAL CO., LTD. (JP) 2017-04-25 — — US disclosed
US-20150232478-A1 COMPOUND HAVING AGONISTIC ACTIVITY ON SOMATOSTATIN RECEPTOR, AND USE THEREOF FOR MEDICAL PURPOSES ONO PHARMACEUTICAL CO., LTD. (JP) 2015-08-20 — — US disclosed
EP-2871179-A1 COMPOUND HAVING AGONISTIC ACTIVITY ON SOMATOSTATIN RECEPTOR, AND USE THEREOF FOR MEDICAL PURPOSES ONO Pharmaceutical Co., Ltd. (JP) 2015-05-13 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170183359-A1 COMPOUND HAVING AGONISTIC ACTIVITY ON SOMATOSTATIN RECEPTOR, AND USE THEREOF FOR MEDICAL PURPOSES SSTR2, SSTR1, SSTR3 CKS1B 4744/4885SKP1 961/4885SKP2 2652/4885
US-20150232478-A1 COMPOUND HAVING AGONISTIC ACTIVITY ON SOMATOSTATIN RECEPTOR, AND USE THEREOF FOR MEDICAL PURPOSES SSTR2, SSTR1, SSTR3 CKS1B 4734/4885SKP1 1112/4885SKP2 2836/4885
US-20180194775-A1 COMPOUND HAVING AGONISTIC ACTIVITY ON SOMATOSTATIN RECEPTOR, AND USE THEREOF FOR MEDICAL PURPOSES SSTR2, SSTR1, SSTR3 CKS1B 4744/4885SKP1 961/4885SKP2 2652/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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