Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.58 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.58 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.58 |
| ▸ | TUBB | P07437 | 1/20 | 0.58 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.58 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.58 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.58 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.58 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.58 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.58 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.58 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.58 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.58 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.58 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.58 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.58 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16698473 | 1.00 | HDAC1 (0.58) | HDAC1HDAC7HDAC2HDAC6TUBB4A | |
| SCHEMBL16698177 | 0.91 | HDAC1 (0.55) | HDAC1HDAC7HDAC2HDAC6TUBB4A | |
| SCHEMBL16698178 | 0.91 | HDAC1 (0.55) | HDAC1HDAC7HDAC2HDAC6TUBB4A | |
| SCHEMBL16698321 | 0.89 | HDAC1 (0.54) | HDAC1HDAC7HDAC2HDAC6TUBB4A | |
| SCHEMBL16698324 | 0.89 | HDAC1 (0.54) | HDAC1HDAC7HDAC2HDAC6TUBB4A | |
| SCHEMBL16698556 | 0.88 | HDAC1 (0.66) | HDAC1HDAC7HDAC2HDAC6TUBB4A | |
| SCHEMBL16698555 | 0.88 | HDAC1 (0.66) | HDAC1HDAC7HDAC2HDAC6TUBB4A | |
| SCHEMBL16697849 | 0.87 | HDAC1 (0.60) | HDAC1HDAC7HDAC2HDAC6TUBB4A | |
| SCHEMBL16697846 | 0.87 | HDAC1 (0.60) | HDAC1HDAC7HDAC2HDAC6TUBB4A | |
| SCHEMBL16697758 | 0.86 | HDAC1 (0.59) | HDAC1HDAC7HDAC2HDAC6TUBB4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9394268-B2 | (E)-1-(5-methoxy-2,2-dimethyl-2H-chromen-8-yl)-3-(4-methoxyphenyl)prop-2-en-1-one and analogs thereof, as well as preparation method and use thereof | SICHUAN UNIVERSITY (CN) | 2016-07-19 | — | — | US | disclosed |
| US-9394268-B2 | (E)-1-(5-methoxy-2,2-dimethyl-2H-chromen-8-yl)-3-(4-methoxyphenyl)prop-2-en-1-one and analogs thereof, as well as preparation method and use thereof | SICHUAN UNIVERSITY (CN) | 2016-07-19 | — | — | US | disclosed |
| US-9394268-B2 | (E)-1-(5-methoxy-2,2-dimethyl-2H-chromen-8-yl)-3-(4-methoxyphenyl)prop-2-en-1-one and analogs thereof, as well as preparation method and use thereof | SICHUAN UNIVERSITY (CN) | 2016-07-19 | — | — | US | disclosed |
| US-20150133659-A1 | (E)-1-(5-METHOXY-2,2-DIMETHYL-2H-CHROMEN-8-YL)-3-(4-METHOXYPHENYL)PROP-2-EN-1-ONE AND ANALOGS THEREOF, AS WELL AS PREPARATION METHOD AND USE THEREOF | SICHUAN UNIVERSITY (CN) | 2015-05-14 | — | — | US | disclosed |
| US-20150133659-A1 | (E)-1-(5-METHOXY-2,2-DIMETHYL-2H-CHROMEN-8-YL)-3-(4-METHOXYPHENYL)PROP-2-EN-1-ONE AND ANALOGS THEREOF, AS WELL AS PREPARATION METHOD AND USE THEREOF | SICHUAN UNIVERSITY (CN) | 2015-05-14 | — | — | US | disclosed |
| US-20150133659-A1 | (E)-1-(5-METHOXY-2,2-DIMETHYL-2H-CHROMEN-8-YL)-3-(4-METHOXYPHENYL)PROP-2-EN-1-ONE AND ANALOGS THEREOF, AS WELL AS PREPARATION METHOD AND USE THEREOF | SICHUAN UNIVERSITY (CN) | 2015-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150133659-A1 | (E)-1-(5-METHOXY-2,2-DIMETHYL-2H-CHROMEN-8-YL)-3-(4-METHOXYPHENYL)PROP-2-EN-1-ONE AND ANALOGS THEREOF, AS WELL AS PREPARATION METHOD AND USE THEREOF | ECE1, CMA1, MME | HDAC1 2136/4885HDAC7 2623/4885HDAC2 1487/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.