Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNIK | Q9UKE5 | 19/20 | 0.76 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.54 |
| ▸ | FLT1 | P17948 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16699316 | 0.88 | TNIK (0.93) | TNIK | |
| SCHEMBL16699356 | 0.87 | TNIK (0.98) | TNIK | |
| SCHEMBL16707044 | 0.86 | TNIK (0.76) | TNIK | |
| SCHEMBL16699254 | 0.86 | TNIK (1.00) | TNIK | |
| SCHEMBL20531096 | 0.86 | TNIK (0.79) | TNIK | |
| SCHEMBL16699832 | 0.86 | TNIK (0.87) | TNIK | |
| SCHEMBL16699753 | 0.84 | TNIK (0.82) | TNIK | |
| SCHEMBL16699103 | 0.83 | TNIK (0.65) | TNIK | |
| SCHEMBL16699609 | 0.82 | TNIK (0.85) | TNIK | |
| SCHEMBL16700432 | 0.81 | TNIK (0.68) | TNIK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2855470-B1 | NOVEL BICYCLIC THIAZOLE COMPOUNDS | CARNA BIOSCIENCES INC (JP) | 2018-10-17 | — | — | EP | disclosed |
| US-9102637-B2 | Bicyclic thiazole compounds | CARNA BIOSCIENCES, INC. (JP) | 2015-08-11 | — | — | US | disclosed |
| US-9102637-B2 | Bicyclic thiazole compounds | CARNA BIOSCIENCES, INC. (JP) | 2015-08-11 | — | — | US | disclosed |
| US-9102637-B2 | Bicyclic thiazole compounds | CARNA BIOSCIENCES, INC. (JP) | 2015-08-11 | — | — | US | disclosed |
| US-20150133656-A1 | NOVEL BICYCLIC THIAZOLE COMPOUNDS | CARNA BIOSCIENCES INC. (JP) | 2015-05-14 | — | — | US | disclosed |
| US-20150133656-A1 | NOVEL BICYCLIC THIAZOLE COMPOUNDS | CARNA BIOSCIENCES INC. (JP) | 2015-05-14 | — | — | US | disclosed |
| US-20150133656-A1 | NOVEL BICYCLIC THIAZOLE COMPOUNDS | CARNA BIOSCIENCES INC. (JP) | 2015-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150133656-A1 | NOVEL BICYCLIC THIAZOLE COMPOUNDS | TNIK, TNNI3K, TNK1 | TNIK 1/4885PDGFRB 2966/4885FLT1 4512/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.