Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 10/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | ABL2 | P42684 | 1/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.38 |
| ▸ | ULK1 | O75385 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16707854 | 1.00 | EGFR (0.47) | EGFRMKNK1ABL1ABL2GRIN2D | |
| SCHEMBL16701094 | 1.00 | EGFR (0.47) | EGFRMKNK1ABL1ABL2GRIN2D | |
| SCHEMBL15534878 | 0.90 | MKNK1 (0.48) | EGFRMKNK1ABL1ABL2 | |
| SCHEMBL16700387 | 0.90 | MKNK1 (0.48) | EGFRMKNK1ABL1ABL2 | |
| SCHEMBL16707855 | 0.90 | MKNK1 (0.48) | EGFRMKNK1ABL1ABL2 | |
| SCHEMBL16708201 | 0.89 | MKNK1 (0.49) | EGFRMKNK1ABL1ABL2 | |
| SCHEMBL16699985 | 0.89 | MKNK1 (0.49) | EGFRMKNK1ABL1ABL2 | |
| SCHEMBL16699981 | 0.89 | MKNK1 (0.49) | EGFRMKNK1ABL1ABL2 | |
| SCHEMBL16700171 | 0.89 | LIMK1 (0.47) | EGFRMKNK1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL16700172 | 0.89 | LIMK1 (0.47) | EGFRMKNK1GRIN2DGRIN3BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150133426-A1 | SUBSTITUTED PYRROLOPYRIMIDINES | Bayer Pharma AG (DE) | 2015-05-14 | — | — | US | claimed |
| US-20150133426-A1 | SUBSTITUTED PYRROLOPYRIMIDINES | Bayer Pharma AG (DE) | 2015-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150133426-A1 | SUBSTITUTED PYRROLOPYRIMIDINES | DPYD, VEGFA, FLT1 | EGFR 1218/4885MKNK1 2315/4885ABL1 515/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.