Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 17/20 | 0.69 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.69 |
| ▸ | MLNR | O43193 | 1/20 | 0.69 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.69 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.69 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.69 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.69 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.69 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.69 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.69 |
| ▸ | DRD2 | P14416 | 1/20 | 0.69 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.69 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.69 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.69 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.69 |
| ▸ | NPY1R | P25929 | 1/20 | 0.69 |
| ▸ | HTR2A | P28223 | 1/20 | 0.69 |
| ▸ | HTR2C | P28335 | 1/20 | 0.69 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.69 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3258716 | 1.00 | ESR1 (0.69) | ESR1ESR2MLNRNR1I2NR3C1 | |
| SCHEMBL115735 | 1.00 | ESR1 (0.69) | ESR1ESR2MLNRNR1I2NR3C1 | |
| Bromide SCHEMBL3639072 | 0.99 | ESR1 (0.68) | ESR1ESR2MLNRNR1I2NR3C1 | |
| SCHEMBL3801089 | 0.93 | ESR1 (0.61) | ESR1ESR2MLNRNR1I2NR3C1 | |
| SCHEMBL3713135 | 0.89 | ESR1 (0.63) | ESR1ESR2MLNRNR1I2NR3C1 | |
| SCHEMBL23350302 | 0.85 | ESR1 (0.66) | ESR1ESR2MLNRNR1I2NR3C1 | |
| SCHEMBL19235625 | 0.82 | ESR1 (0.73) | ESR1ESR2MLNRNR1I2NR3C1 | |
| Lasofoxifene SCHEMBL9885582 | 0.82 | ESR1 (1.00) | ESR1ESR2MLNRNR1I2NR3C1 | |
| Lasofoxifene SCHEMBL3774585 | 0.82 | ESR1 (1.00) | ESR1ESR2MLNRNR1I2NR3C1 | |
| Lasofoxifene SCHEMBL3774592 | 0.82 | ESR1 (1.00) | ESR1ESR2MLNRNR1I2NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018195202-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER | PELLFICURE PHARMACEUTICALS INC. (US) | 2018-10-25 | — | — | WO | disclosed |
| EP-3083995-A2 | MEANS AND METHODS FOR TYPING A BREAST CANCER PATIENT AND ASSIGNING THERAPY BASED ON THE TYPING | Stichting Het Nederlands Kanker Instituut- Antoni van Leeuwenhoek Ziekenhuis (NL) | 2016-10-26 | — | — | EP | disclosed |
| EP-3068433-A1 | METHODS AND PHARMACEUTICAL FORMULATIONS FOR TREATMENT OF SELECTIVE ESTROGEN-RECEPTOR MODULATOR-INDUCED ADVERSE DRUG REACTIONS | Limoxifen B.V. (NL) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015093948-A2 | MEANS AND METHODS FOR TYPING A BREAST CANCER PATIENT AND ASSIGNING THERAPY BASED ON THE TYPING | Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis (NL) | 2015-06-25 | — | — | WO | disclosed |
| WO-2015069115-A1 | METHODS AND PHARMACEUTICAL FORMULATIONS FOR TREATMENT OF SELECTIVE ESTROGEN-RECEPTOR MODULATOR-INDUCED ADVERSE DRUG REACTIONS | LIMBIC BRAIN COMPANY B.V. (NL) | 2015-05-14 | — | — | WO | disclosed |