Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.58 |
| ▸ | JAK1 | P23458 | 1/20 | 0.58 |
| ▸ | NOS1 | P29475 | 4/20 | 0.58 |
| ▸ | AXL | P30530 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | IDO1 | P14902 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | METAP2 | P50579 | 1/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.48 |
| ▸ | DHPS | P49366 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16703680 | 0.81 | JAK2 (0.58) | JAK2JAK1NOS1AXLNPC1 | |
| SCHEMBL20239474 | 0.81 | JAK2 (0.58) | JAK2JAK1NOS1AXLNPC1 | |
| SCHEMBL18193501 | 0.81 | JAK2 (0.58) | JAK2JAK1NOS1AXLNPC1 | |
| SCHEMBL8306066 | 0.81 | JAK2 (0.68) | JAK2JAK1NOS1AXLNPC1 | |
| SCHEMBL23593790 | 0.77 | JAK2 (0.54) | JAK2JAK1NOS1AXLNPC1 | |
| SCHEMBL21600866 | 0.77 | JAK2 (0.58) | JAK2JAK1NOS1AXLNPC1 | |
| SCHEMBL11733937 | 0.77 | JAK2 (0.54) | JAK2JAK1NOS1AXLNPC1 | |
| SCHEMBL21964331 | 0.77 | JAK2 (0.58) | JAK2JAK1NOS1AXLNPC1 | |
| SCHEMBL17738849 | 0.77 | KDM4E (0.55) | JAK2JAK1NOS1AXLNPC1 | |
| SCHEMBL28163797 | 0.77 | JAK2 (0.58) | JAK2JAK1NOS1AXLNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3066100-A1 | (AZA)PYRIDOPYRAZOLOPYRIMIDINONES AND INDAZOLOPYRIMIDINONES AS INHIBITORS OF FIBRINOLYSIS | Bayer Pharma Aktiengesellschaft (DE) | 2016-09-14 | — | — | EP | disclosed |
| WO-2015067549-A1 | (AZA)PYRIDOPYRAZOLOPYRIMIDINONES AND INDAZOLOPYRIMIDINONES AS INHIBITORS OF FIBRINOLYSIS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2015-05-14 | — | — | WO | disclosed |