Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 8/20 | 0.56 |
| ▸ | GSK3A | P49840 | 5/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.38 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.37 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.37 |
| ▸ | KCNE1 | P15382 | 2/20 | 0.37 |
| ▸ | KCNQ1 | P51787 | 2/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16702726 | 0.85 | GSK3B (0.56) | GSK3BGSK3AMAPTPTGS1SCN9A | |
| SCHEMBL16702508 | 0.82 | GSK3B (0.52) | GSK3BGSK3AMAPTPTGS1SCN9A | |
| SCHEMBL16702502 | 0.81 | GSK3B (0.77) | GSK3BGSK3AMAPTTRPV1 | |
| SCHEMBL16702819 | 0.81 | GSK3B (0.71) | GSK3BGSK3AMAPTPTGS1 | |
| SCHEMBL16702480 | 0.81 | GSK3B (0.56) | GSK3BGSK3AMAPTPTGS1SCN9A | |
| SCHEMBL16712878 | 0.80 | GSK3B (0.57) | GSK3BGSK3AMAPTPTGS1SCN9A | |
| SCHEMBL16703193 | 0.80 | GSK3B (0.55) | GSK3BGSK3AMAPTPTGS1SCN9A | |
| SCHEMBL16702627 | 0.80 | GSK3B (0.49) | GSK3BGSK3AMAPTSCN9AMEN1 | |
| SCHEMBL16702473 | 0.79 | GSK3B (0.56) | GSK3BGSK3AMAPTMEN1KMT2A | |
| SCHEMBL16702854 | 0.79 | GSK3B (0.52) | GSK3BGSK3AMAPTPTGS1SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3066093-A1 | GSK-3 INHIBITORS | Bristol-Myers Squibb Company (US) | 2016-09-14 | — | — | EP | disclosed |
| WO-2015069594-A1 | GSK-3 INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-05-14 | — | — | WO | disclosed |