Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | DPYD | Q12882 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | THPO | P40225 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HBB | P68871 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDM3B | Q7LBC6 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1210894 | 0.81 | GAA (0.50) | GAADPYDLMNAMAPTALDH1A1 | |
| SCHEMBL6601546 | 0.76 | GAA (0.45) | GAADPYDLMNAMAPTALDH1A1 | |
| SCHEMBL4394659 | 0.76 | GAA (0.45) | GAADPYDLMNAMAPTALDH1A1 | |
| SCHEMBL127493 | 0.74 | KDM3B (0.64) | GAADPYDLMNAMAPTALDH1A1 | |
| SCHEMBL6524027 | 0.72 | GAA (0.50) | GAADPYDLMNAMAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL11439523 | 0.72 | KDM3B (0.62) | GAADPYDLMNAMAPTALDH1A1 | |
| SCHEMBL190958 | 0.72 | GAA (0.50) | GAADPYDLMNAMAPTALDH1A1 | |
| Water SCHEMBL4487821 | 0.72 | KDM3B (0.62) | GAADPYDLMNAMAPTALDH1A1 | |
| SCHEMBL65890 | 0.71 | GAA (0.48) | GAADPYDLMNAMAPTALDH1A1 | |
| SCHEMBL933035 | 0.71 | DPYD (0.48) | GAADPYDLMNAMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3066096-A1 | SUBSTITUTED URACILS AS CHYMASE INHIBITORS | Bayer Pharma Aktiengesellschaft (DE) | 2016-09-14 | — | — | EP | disclosed |
| WO-2015067651-A1 | SUBSTITUTED URACILS AS CHYMASE INHIBITORS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2015-05-14 | — | — | WO | disclosed |