Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 19/20 | 1.00 |
| ▸ | MAPT | P10636 | 9/20 | 1.00 |
| ▸ | GSK3A | P49840 | 12/20 | 0.84 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19558456 | 1.00 | GSK3B (1.00) | GSK3BMAPTGSK3A | |
| SCHEMBL16710967 | 1.00 | GSK3B (1.00) | GSK3BMAPTGSK3A | |
| SCHEMBL16710968 | 0.93 | MAPT (1.00) | GSK3BMAPTGSK3A | |
| SCHEMBL19558485 | 0.93 | MAPT (1.00) | GSK3BMAPTGSK3A | |
| SCHEMBL19558469 | 0.93 | MAPT (1.00) | GSK3BMAPTGSK3A | |
| SCHEMBL16710978 | 0.91 | GSK3B (1.00) | GSK3BMAPTGSK3A | |
| SCHEMBL31065686 | 0.91 | GSK3B (1.00) | GSK3BMAPTGSK3A | |
| SCHEMBL16704086 | 0.85 | GSK3B (1.00) | GSK3BMAPTGSK3A | |
| SCHEMBL16710993 | 0.84 | GSK3B (0.85) | GSK3BMAPTGSK3A | |
| SCHEMBL19558471 | 0.84 | GSK3B (0.85) | GSK3BMAPTGSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9809573-B2 | Substituted pyridine derivatives useful as GSK-3 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-11-07 | — | — | US | disclosed |
| EP-3066092-A1 | SUBSTITUTED PYRIDINE DERIVATIVES USEFUL AS GSK-3 INHIBITORS | Bristol-Myers Squibb Company (US) | 2016-09-14 | — | — | EP | disclosed |
| WO-2015069593-A1 | SUBSTITUTED PYRIDINE DERIVATIVES USEFUL AS GSK-3 INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-05-14 | — | — | WO | disclosed |