Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 16/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | FNTA | P49354 | 1/20 | 0.44 |
| ▸ | FNTB | P49356 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16309454 | 0.90 | GRM5 (0.60) | GRM5 | |
| SCHEMBL16704469 | 0.90 | GRM5 (0.59) | GRM5 | |
| SCHEMBL16704491 | 0.89 | GRM5 (0.53) | GRM5ALDH1A1 | |
| SCHEMBL16704480 | 0.89 | GRM5 (0.54) | GRM5 | |
| SCHEMBL16704485 | 0.88 | GRM5 (0.54) | GRM5 | |
| SCHEMBL16704487 | 0.86 | GRM5 (0.50) | GRM5 | |
| SCHEMBL16704522 | 0.86 | GRM5 (0.56) | GRM5 | |
| SCHEMBL16704481 | 0.85 | GRM5 (0.59) | GRM5 | |
| SCHEMBL16704472 | 0.85 | GRM5 (0.53) | GRM5 | |
| SCHEMBL16309393 | 0.85 | GRM5 (0.54) | GRM5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150216863-A1 | SUBSTITUTED BICYCLIC ALKOXY PYRAZOLE ANALOGS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS | UNIV VANDERBILT (US) | 2015-08-06 | — | — | US | disclosed |
| US-9029366-B2 | Substituted bicyclic alkoxy pyrazole analogs as allosteric modulators of mGluR5 receptors | VANDERBILT UNIVERSITY (US) | 2015-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150216863-A1 | SUBSTITUTED BICYCLIC ALKOXY PYRAZOLE ANALOGS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS | GRM5, GRIK5, GRM3 | GRM5 1/4885ALDH1A1 4319/4885MAPT 701/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.