Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 9/20 | 0.52 |
| ▸ | MTOR | P42345 | 2/20 | 0.52 |
| ▸ | ALPL | P05186 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13597970 | 0.92 | PIK3CA (0.52) | PIK3CAMTORKMT2AEGFRCDK2 | |
| SCHEMBL8006058 | 0.91 | PIK3CA (0.54) | PIK3CAMTORKMT2AEGFRCDK2 | |
| SCHEMBL8008169 | 0.91 | PIK3CA (0.50) | PIK3CAMTORKMT2AEGFRCDK2 | |
| SCHEMBL8005712 | 0.90 | PIK3CA (0.53) | PIK3CAMTOREGFRCDK2MAPT | |
| SCHEMBL8008105 | 0.90 | PIK3CA (0.53) | PIK3CAMTOREGFRCDK2MAPK1 | |
| SCHEMBL7996257 | 0.90 | PIK3CA (0.55) | PIK3CAMTORALPLEGFRCDK2 | |
| SCHEMBL8006078 | 0.90 | PIK3CA (0.56) | PIK3CAMTORKMT2AEGFRCDK2 | |
| SCHEMBL8008138 | 0.90 | PIK3CA (0.52) | PIK3CAMTOREGFRCDK2ALDH1A1 | |
| SCHEMBL1552132 | 0.90 | PIK3CA (0.55) | PIK3CAMTOREGFRCDK2ALDH1A1 | |
| SCHEMBL13597813 | 0.90 | PIK3CA (0.54) | PIK3CAMTOREGFRCDK2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9029411-B2 | Thiophenes and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2015-05-12 | — | — | US | disclosed |