Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 9/20 | 0.52 |
| ▸ | MTOR | P42345 | 2/20 | 0.52 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | FNTA | P49354 | 1/20 | 0.37 |
| ▸ | FNTB | P49356 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.36 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8008066 | 1.00 | PIK3CA (0.52) | PIK3CAMTORP2RX7PIK3R1ATM | |
| SCHEMBL7996116 | 1.00 | PIK3CA (0.52) | PIK3CAMTORP2RX7PIK3R1ATM | |
| SCHEMBL17244453 | 0.94 | PIK3CA (0.53) | PIK3CAMTORP2RX7PIK3R1ATM | |
| SCHEMBL8006078 | 0.90 | PIK3CA (0.56) | PIK3CAMTORPIK3R1ATMEGFR | |
| SCHEMBL8006058 | 0.88 | PIK3CA (0.54) | PIK3CAMTORPIK3R1ATMEGFR | |
| SCHEMBL8008105 | 0.87 | PIK3CA (0.53) | PIK3CAMTORPIK3R1ATMEGFR | |
| SCHEMBL8005712 | 0.87 | PIK3CA (0.53) | PIK3CAMTORPIK3R1ATMEGFR | |
| SCHEMBL7996257 | 0.87 | PIK3CA (0.55) | PIK3CAMTORPIK3R1EGFRCDK2 | |
| SCHEMBL8005706 | 0.86 | PIK3CA (0.58) | PIK3CAMTORPIK3R1CNR1CNR2 | |
| SCHEMBL8011693 | 0.86 | PIK3CA (0.52) | PIK3CAMTORPIK3R1CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2250160-B1 | THIOPHENES AND THEIR USE AS PHOSPHATIDYLINOSITOL 3-KINASE (PI3K) INHIBITORS | MILLENNIUM PHARM INC (US) | 2015-11-11 | — | — | EP | disclosed |
| US-9029411-B2 | Thiophenes and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2015-05-12 | — | — | US | disclosed |