Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 15/20 | 0.59 |
| ▸ | PDE1A | P54750 | 5/20 | 0.52 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 2/20 | 0.33 |
| ▸ | PDE8A | O60658 | 2/20 | 0.33 |
| ▸ | PDE5A | O76074 | 2/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.33 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.33 |
| ▸ | PDE7B | Q9NP56 | 2/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.33 |
| ▸ | PDE9A | O76083 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL798721 | 0.93 | PDE4A (0.59) | PDE4APDE1APDE1BPDE2APDE8A | |
| SCHEMBL16705458 | 0.81 | PDE4A (0.52) | PDE4APDE1APDE2APDE8APDE5A | |
| SCHEMBL17610088 | 0.78 | PDE1A (0.81) | PDE4APDE1APDE1BPDE2APDE8A | |
| SCHEMBL4910753 | 0.74 | PDE4A (1.00) | PDE4APDE1APDE2APDE8APDE5A | |
| SCHEMBL798241 | 0.71 | PDE1A (0.53) | PDE4APDE1APDE1BPDE2APDE8A | |
| SCHEMBL26905231 | 0.70 | PDE1A (0.80) | PDE4APDE1APDE1BPDE2APDE8A | |
| SCHEMBL17508445 | 0.69 | PDE1A (0.79) | PDE4APDE1APDE1BPDE2APDE8A | |
| SCHEMBL31571927 | 0.69 | PDE1A (0.78) | PDE4APDE1APDE1BPDE2APDE8A | |
| SCHEMBL31571922 | 0.69 | PDE1A (0.78) | PDE4APDE1APDE1BPDE2APDE8A | |
| SCHEMBL31571924 | 0.69 | PDE1A (0.78) | PDE4APDE1APDE1BPDE2APDE8A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2358723-B1 | 4,5,7,8-tetrahydro-2H-imidazo[1,2-a]pyrrolo[3,4-e]pyrimidine compounds as PDE1 inhibitors | INTRA CELLULAR THERAPIES INC (US) | 2015-05-13 | — | — | EP | disclosed |