Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 20/20 | 0.55 |
| ▸ | PDE5A | O76074 | 5/20 | 0.55 |
| ▸ | PDE3B | Q13370 | 5/20 | 0.55 |
| ▸ | PDE11A | Q9HCR9 | 5/20 | 0.55 |
| ▸ | PDE7B | Q9NP56 | 5/20 | 0.55 |
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.55 |
| ▸ | PDE2A | O00408 | 4/20 | 0.54 |
| ▸ | PDE8A | O60658 | 4/20 | 0.54 |
| ▸ | PDE9A | O76083 | 3/20 | 0.52 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL798395 | 0.92 | PDE4A (0.55) | PDE4APDE5APDE3BPDE11APDE7B | |
| SCHEMBL16576765 | 0.80 | PDE4A (0.82) | PDE4APDE5APDE3BPDE11APDE7B | |
| SCHEMBL798700 | 0.79 | PDE4A (0.76) | PDE4APDE5APDE3BPDE11APDE7B | |
| SCHEMBL15427617 | 0.79 | PDE4A (0.81) | PDE4APDE5APDE3BPDE11APDE7B | |
| SCHEMBL798393 | 0.79 | PDE4A (0.82) | PDE4APDE5APDE3BPDE11APDE7B | |
| SCHEMBL772318 | 0.78 | PDE4A (0.71) | PDE4APDE5APDE3BPDE11APDE7B | |
| SCHEMBL798413 | 0.77 | PDE4A (0.78) | PDE4APDE5APDE3BPDE11APDE7B | |
| SCHEMBL798734 | 0.77 | PDE4A (0.84) | PDE4APDE5APDE3BPDE11APDE7B | |
| SCHEMBL798736 | 0.77 | PDE4A (0.78) | PDE4APDE5APDE3BPDE11APDE7B | |
| SCHEMBL7906661 | 0.77 | PDE4A (0.84) | PDE4APDE5APDE3BPDE11APDE7B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2358723-B1 | 4,5,7,8-tetrahydro-2H-imidazo[1,2-a]pyrrolo[3,4-e]pyrimidine compounds as PDE1 inhibitors | INTRA CELLULAR THERAPIES INC (US) | 2015-05-13 | — | — | EP | disclosed |