Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 13/20 | 1.00 |
| ▸ | PARP15 | Q460N3 | 7/20 | 1.00 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 1.00 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.55 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.48 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.48 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.48 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6527611 | 0.93 | PARP10 (1.00) | PARP10PARP15PARP2HRH3CHEK2 | |
| SCHEMBL12735790 | 0.86 | PARP10 (0.79) | PARP10PARP15PARP2CHEK2 | |
| SCHEMBL2885506 | 0.85 | PARP10 (0.73) | PARP10PARP15PARP2KMT2ACDK2 | |
| Hydrochloric Acid SCHEMBL31752833 | 0.84 | PARP10 (0.77) | PARP10PARP15PARP2CHEK2 | |
| SCHEMBL29972881 | 0.83 | PARP10 (0.75) | PARP10PARP15PARP2HRH3CHEK2 | |
| SCHEMBL12420703 | 0.81 | PARP10 (0.73) | PARP10PARP15PARP2KMT2A | |
| SCHEMBL1532862 | 0.80 | PARP10 (0.74) | PARP10PARP15PARP2ALDH1A1KMT2A | |
| SCHEMBL4117982 | 0.80 | PARP10 (0.71) | PARP10PARP15PARP2ALDH1A1KMT2A | |
| SCHEMBL12420700 | 0.80 | PARP10 (0.74) | PARP10PARP15PARP2ALDH1A1KMT2A | |
| SCHEMBL1532841 | 0.80 | PARP10 (0.74) | PARP10PARP15PARP2ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486014-A1 | MODULATORS OF G PROTEIN-COUPLED RECEPTOR 88 | Bristol-Myers Squibb Company (US) | 2012-08-15 | — | — | EP | disclosed |
| WO-2011044212-A1 | MODULATORS OF G PROTEIN-COUPLED RECEPTOR 88 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-04-14 | — | — | WO | disclosed |