Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.85 |
| ▸ | BTK | Q06187 | 8/20 | 0.85 |
| ▸ | JAK3 | P52333 | 7/20 | 0.85 |
| ▸ | JAK2 | O60674 | 4/20 | 0.85 |
| ▸ | JAK1 | P23458 | 3/20 | 0.85 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.85 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.71 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.68 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.63 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.61 |
| ▸ | ESR1 | P03372 | 1/20 | 0.61 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.61 |
| ▸ | HTR1A | P08908 | 1/20 | 0.61 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.61 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.61 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.61 |
| ▸ | DRD1 | P21728 | 1/20 | 0.61 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.61 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.61 |
| ▸ | PDE4A | P27815 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16370848 | 0.93 | EGFR (0.82) | EGFRBTKJAK3JAK2JAK1 | |
| SCHEMBL30672748 | 0.93 | EGFR (0.82) | EGFRBTKJAK3JAK2JAK1 | |
| SCHEMBL15453409 | 0.92 | EGFR (1.00) | EGFRBTKJAK3JAK2JAK1 | |
| SCHEMBL16706346 | 0.90 | EGFR (0.86) | EGFRBTKJAK3JAK2JAK1 | |
| SCHEMBL16706359 | 0.88 | NUAK1 (0.68) | EGFRBTKJAK3JAK2JAK1 | |
| SCHEMBL16706350 | 0.84 | EGFR (0.64) | EGFRBTKJAK3JAK2JAK1 | |
| SCHEMBL16706318 | 0.83 | EGFR (0.69) | EGFRBTKJAK3JAK2JAK1 | |
| SCHEMBL18018785 | 0.83 | MAP3K7 (1.00) | EGFRBTKJAK3JAK2JAK1 | |
| SCHEMBL29937838 | 0.83 | JAK3 (1.00) | EGFRBTKJAK3JAK2JAK1 | |
| SCHEMBL15453375 | 0.83 | JAK3 (1.00) | EGFRBTKJAK3JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9920074-B2 | Heterocyclic compounds and uses thereof | ACEA BIOSCIENCES INC. (US) | 2018-03-20 | — | — | US | disclosed |
| US-20170029442-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | ACEA Therapeutics, Inc. | 2017-02-02 | — | — | US | disclosed |
| US-9464089-B2 | Heterocyclic compounds and uses thereof | ACEA BIOSCIENCES INC. (US) | 2016-10-11 | — | — | US | disclosed |
| US-20150133457-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | ACEA BIOSCIENCES INC. | 2015-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170029442-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | BMX, BLK, BTK | EGFR 16/4885BTK 3/4885JAK3 30/4885 |
| US-20150133457-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | BMX, BLK, BTK | EGFR 16/4885BTK 3/4885JAK3 30/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.