Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 12/20 | 0.59 |
| ▸ | HSP90AB1 | P08238 | 12/20 | 0.59 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.36 |
| ▸ | PIR | O00625 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16701896 | 0.94 | HSP90AA1 (0.68) | HSP90AA1HSP90AB1CREBBPP2RY12ITGB3 | |
| SCHEMBL16710347 | 0.94 | HSP90AA1 (0.61) | HSP90AA1HSP90AB1PIR | |
| SCHEMBL16710343 | 0.93 | HSP90AA1 (0.60) | HSP90AA1HSP90AB1PIR | |
| SCHEMBL16710346 | 0.93 | HSP90AA1 (0.64) | HSP90AA1HSP90AB1P2RY12PIR | |
| SCHEMBL16710342 | 0.92 | HSP90AA1 (0.59) | HSP90AA1HSP90AB1P2RY12 | |
| SCHEMBL16702000 | 0.87 | HSP90AA1 (0.70) | HSP90AA1HSP90AB1PIR | |
| SCHEMBL16701921 | 0.86 | HSP90AA1 (0.69) | HSP90AA1HSP90AB1PIR | |
| SCHEMBL16702078 | 0.86 | HSP90AA1 (0.74) | HSP90AA1HSP90AB1P2RY12PIR | |
| SCHEMBL16702118 | 0.86 | HSP90AA1 (0.57) | HSP90AA1HSP90AB1AKR1C3AKR1C2 | |
| SCHEMBL16702447 | 0.85 | HSP90AA1 (0.68) | HSP90AA1HSP90AB1P2RY12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10745386-B2 | Coumarin based HSP90 inhibitors with urea and ether substituents | UNIVERSITY OF KANSAS (US) | 2020-08-18 | — | — | US | disclosed |
| US-20190023698-A1 | COUMARIN BASED HSP90 INHIBITORS WITH UREA AND ETHER SUBSTITUENTS | UNIVERSITY OF KANSAS (US) | 2019-01-24 | — | — | US | disclosed |
| US-10030006-B2 | Coumarin based Hsp90 inhibitors with urea and ether substituents | UNIVERSITY OF KANSAS (US) | 2018-07-24 | — | — | US | disclosed |
| US-20160289217-A1 | COUMARIN BASED HSP90 INHIBITORS WITH UREA AND ETHER SUBSTITUENTS | UNIVERSITY OF KANSAS (US) | 2016-10-06 | — | — | US | disclosed |
| WO-2015070238-A2 | COUMARIN BASED HSP90 INHIBITORS WITH UREA AND ETHER SUBSTITUENTS | THE UNIVERSITY OF KANSAS (US) | 2015-05-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10745386-B2 | Coumarin based HSP90 inhibitors with urea and ether substituents | HSP90B1, HSP90AA1, HSP90AB1 | HSP90AA1 2/4885HSP90AB1 3/4885CREBBP 619/4885 |
| US-10030006-B2 | Coumarin based Hsp90 inhibitors with urea and ether substituents | HSP90B1, HSP90AA1, HSP90AB1 | HSP90AA1 2/4885HSP90AB1 3/4885CREBBP 591/4885 |
| US-20160289217-A1 | COUMARIN BASED HSP90 INHIBITORS WITH UREA AND ETHER SUBSTITUENTS | HSP90B1, HSP90AA1, HSP90AB1 | HSP90AA1 2/4885HSP90AB1 3/4885CREBBP 591/4885 |
| US-20190023698-A1 | COUMARIN BASED HSP90 INHIBITORS WITH UREA AND ETHER SUBSTITUENTS | HSP90B1, HSP90AA1, HSP90AB1 | HSP90AA1 2/4885HSP90AB1 3/4885CREBBP 591/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.