Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 20/20 | 0.61 |
| ▸ | IKBKB | O14920 | 1/20 | 0.61 |
| ▸ | MARK3 | P27448 | 2/20 | 0.57 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.57 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.57 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.57 |
| ▸ | KIT | P10721 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | AKT1 | P31749 | 1/20 | 0.57 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.52 |
| ▸ | JAK2 | O60674 | 2/20 | 0.52 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.52 |
| ▸ | CDK2 | P24941 | 1/20 | 0.52 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.52 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | GSK3B | P49841 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4882434 | 0.83 | CHEK1 (0.84) | CHEK1IKBKBMARK3MARK2AURKB | |
| SCHEMBL4849220 | 0.80 | CHEK1 (0.84) | CHEK1IKBKBMARK3MARK2AURKB | |
| SCHEMBL4848513 | 0.80 | CHEK1 (0.78) | CHEK1IKBKBMARK3MARK2AURKB | |
| SCHEMBL6343450 | 0.79 | CHEK1 (0.44) | CHEK1IKBKBMARK3MARK2AURKB | |
| SCHEMBL16712626 | 0.79 | CHEK1 (0.56) | CHEK1IKBKBMARK3MARK2AURKB | |
| SCHEMBL16712638 | 0.77 | CHEK1 (0.49) | CHEK1IKBKBMARK3MARK2AURKB | |
| SCHEMBL4859458 | 0.75 | CHEK1 (0.73) | CHEK1AURKBCHEK2PDPK1AURKA | |
| SCHEMBL16712639 | 0.74 | CHEK1 (0.46) | CHEK1IKBKBMARK3MARK2AURKB | |
| SCHEMBL4848005 | 0.74 | CHEK1 (0.74) | CHEK1IKBKBMARK3MARK2AURKB | |
| SCHEMBL4856189 | 0.74 | CHEK1 (0.82) | CHEK1IKBKBMARK3MARK2AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1606268-B1 | 5,10-DIHYDRO-11H-DIBENZO[B,E][1,4]DIAZEPIN-11-ONE AS KINASE INHIBITORS | ABBVIE INC (US) | 2015-05-20 | — | — | EP | claimed |