Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 known ✓ | P20309 | 11/20 | 0.42 |
| ▸ | CHRM2 known ✓ | P08172 | 10/20 | 0.42 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 8/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL73892 | 0.98 | DAO (0.45) | DAOCHRM3CHRM2CHRM1CES2 | |
| Fluoride SCHEMBL14940050 | 0.96 | DAO (0.43) | DAOCHRM3CHRM2CHRM1CES2 | |
| Bromomethane SCHEMBL5389919 | 0.92 | CHRM3 (0.41) | DAOCHRM3CHRM2CHRM1CES2 | |
| Iodomethane SCHEMBL6402613 | 0.92 | CHRM3 (0.41) | DAOCHRM3CHRM2CHRM1CES2 | |
| Fumaric Acid SCHEMBL17821282 | 0.89 | HCAR2 (0.49) | DAOCHRM3CHRM2CHRM1CES2 | |
| SCHEMBL73656 | 0.86 | CHRM3 (0.50) | DAOCHRM3CHRM2CHRM1CYP2C9 | |
| SCHEMBL5964331 | 0.86 | CHRM3 (0.50) | DAOCHRM3CHRM2CHRM1CYP2C9 | |
| SCHEMBL12633531 | 0.84 | CHRM3 (0.40) | DAOCHRM3CHRM2CHRM1CES2 | |
| SCHEMBL27661802 | 0.83 | SMN1; SMN2 (0.43) | CHRM3CHRM2CHRM1CYP2C9GAA | |
| SCHEMBL27681373 | 0.83 | CHRM3 (0.43) | CHRM3CHRM2CHRM1CYP2C9GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150141387-A1 | PHARMACEUTICAL PRODUCT COMPRISING A P38 KINASE INHIBITOR AND A SECOND ACTIVE INGREDIENT | ASTRAZENECA UK LIMITED (GB) | 2015-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150141387-A1 | PHARMACEUTICAL PRODUCT COMPRISING A P38 KINASE INHIBITOR AND A SECOND ACTIVE INGREDIENT | NR3C2, GRK4, PTGER2 | CHRM3 629/4885CHRM2 1106/4885ADRA1A 70/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.