Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.56 |
| ▸ | KDR | P35968 | 9/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.52 |
| ▸ | EGFR | P00533 | 5/20 | 0.50 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.50 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1227597 | 0.87 | MAP2K1 (0.55) | MAP2K1KDRMAPK14EGFRERBB2 | |
| SCHEMBL1227820 | 0.86 | KDR (0.60) | MAP2K1KDRMAPK14EGFRERBB2 | |
| SCHEMBL1226304 | 0.86 | MAP2K1 (0.54) | MAP2K1KDRMAPK14EGFRERBB2 | |
| SCHEMBL32664156 | 0.76 | MAP2K1 (0.50) | MAP2K1KDRMAPK14EGFRERBB2 | |
| SCHEMBL4046095 | 0.76 | EGFR (0.60) | MAP2K1KDRMAPK14EGFRERBB2 | |
| SCHEMBL4044082 | 0.76 | KDR (0.52) | MAP2K1KDRMAPK14EGFRERBB2 | |
| SCHEMBL1730410 | 0.75 | NR1H2 (0.73) | MAP2K1KDRMAPK14NR1H2 | |
| SCHEMBL4102366 | 0.75 | MAP2K1 (0.49) | MAP2K1KDRMAPK14EGFRERBB2 | |
| SCHEMBL6112565 | 0.75 | MAP2K1 (0.59) | MAP2K1KDRMAPK14EGFRERBB2 | |
| SCHEMBL4101070 | 0.75 | MAP2K1 (0.44) | MAP2K1KDRMAPK14EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1497019-B1 | PYRROLO-TRIAZINE ANILINE COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2015-05-20 | — | — | EP | disclosed |