Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.60 |
| ▸ | NPC1 | O15118 | 5/20 | 0.60 |
| ▸ | RAB9A | P51151 | 5/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.60 |
| ▸ | MEN1 | O00255 | 5/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | EIF4E | P06730 | 9/20 | 0.53 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.50 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1505212 | 0.88 | NPC1 (0.60) | KDM4ENPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL14106256 | 0.88 | KDM4E (0.52) | KDM4ENPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL12171823 | 0.85 | EIF4E (0.60) | KDM4ENPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL17336823 | 0.84 | KDM4E (0.64) | KDM4ENPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL1505261 | 0.84 | KDM4E (0.62) | KDM4ENPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL12171986 | 0.84 | KDM4E (0.64) | KDM4ENPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL1505287 | 0.84 | SREBF2 (0.65) | KDM4ENPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL7215552 | 0.84 | KDM4E (0.73) | KDM4ENPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL16716671 | 0.83 | KDM4E (0.65) | KDM4ENPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL12796866 | 0.83 | KDM4E (0.63) | KDM4ENPC1RAB9ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2301538-B1 | Compounds for nonsense suppression, and methods for their use | PTC THERAPEUTICS INC (US) | 2015-05-20 | — | — | EP | disclosed |