Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 4/20 | 0.36 |
| ▸ | CSNK1E | P49674 | 4/20 | 0.36 |
| ▸ | TNF | P01375 | 6/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 6/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 4/20 | 0.31 |
| ▸ | JAK3 | P52333 | 3/20 | 0.31 |
| ▸ | JAK2 | O60674 | 2/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | MYT1 | Q01538 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16700166 | 0.88 | CASR (0.36) | CSNK1DCSNK1E | |
| SCHEMBL16699389 | 0.80 | CASR (0.31) | CSNK1DCSNK1E | |
| SCHEMBL16700251 | 0.77 | DRD3 (0.31) | — | |
| SCHEMBL17527367 | 0.76 | CSNK1E (0.51) | CSNK1DCSNK1E | |
| SCHEMBL16718783 | 0.74 | CSNK1E (0.49) | CSNK1DCSNK1E | |
| SCHEMBL16698729 | 0.74 | CD38 (0.31) | — | |
| SCHEMBL28611830 | 0.68 | CSNK1D (0.36) | CSNK1DCSNK1ECDK1MYT1 | |
| SCHEMBL16699410 | 0.68 | CSNK1E (0.40) | CSNK1DCSNK1EJAK3 | |
| SCHEMBL16701047 | 0.68 | CSNK1E (0.58) | CSNK1DCSNK1E | |
| SCHEMBL16711325 | 0.68 | CSNK1E (0.57) | CSNK1DCSNK1E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068785-A1 | SUBSTITUTED 4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRAZINE DERIVATIVES AS CASEIN KINASE 1 D/E INHIBITORS | Bristol-Myers Squibb Company (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073763-A1 | SUBSTITUTED 4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRAZINE DERIVATIVES AS CASEIN KINASE 1 D/E INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-05-21 | — | — | WO | disclosed |