SCHEMBL16718786

SCHEMBL16718786

CC1(NC(=O)c2c(-c3ccc(F)c(Cl)c3)nn3c2CN(C(N)=O)CC3)CC(O)C1

nearest known ligand 0.53

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CSNK1E P49674 20/20 0.53
CSNK1D P48730 16/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16700270 0.88 CSNK1E (0.65) CSNK1ECSNK1D
SCHEMBL16700118 0.86 CSNK1E (0.46) CSNK1ECSNK1D
SCHEMBL16698479 0.84 CSNK1E (0.52) CSNK1ECSNK1D
SCHEMBL16700447 0.84 CSNK1E (0.53) CSNK1ECSNK1D
SCHEMBL16699702 0.83 CSNK1E (0.51) CSNK1ECSNK1D
SCHEMBL18171133 0.83 CSNK1E (0.64) CSNK1ECSNK1D
SCHEMBL16708923 0.82 CSNK1E (0.63) CSNK1ECSNK1D
SCHEMBL16730896 0.82 CSNK1E (0.63) CSNK1ECSNK1D
SCHEMBL16700129 0.82 CSNK1E (0.63) CSNK1ECSNK1D
SCHEMBL21130988 0.82 CSNK1E (0.63) CSNK1ECSNK1D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3068785-A1 SUBSTITUTED 4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRAZINE DERIVATIVES AS CASEIN KINASE 1 D/E INHIBITORS Bristol-Myers Squibb Company (US) 2016-09-21 EP disclosed
WO-2015073763-A1 SUBSTITUTED 4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRAZINE DERIVATIVES AS CASEIN KINASE 1 D/E INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2015-05-21 WO disclosed