Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.33 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.33 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.33 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.33 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11903802 | 0.88 | CHRM2 (0.40) | KDM4EALDH1A1KCNH2GPR119PIK3CA | |
| SCHEMBL1670842 | 0.87 | KDM4E (0.39) | KDM4EALDH1A1KCNH2GPR119PIK3CA | |
| SCHEMBL1672013 | 0.83 | P2RY14 (0.41) | KCNH2GPR119PIK3CAPRKAA2CNR1 | |
| SCHEMBL1668353 | 0.82 | P2RY14 (0.39) | KDM4EALDH1A1KCNH2GPR119PIK3CA | |
| SCHEMBL1668410 | 0.81 | KDM4E (0.49) | KDM4EALDH1A1KCNH2GPR119PIK3CA | |
| SCHEMBL1668229 | 0.81 | CNR1 (0.37) | KDM4EALDH1A1KCNH2GPR119PIK3CA | |
| SCHEMBL1668510 | 0.81 | HIF1A (0.38) | KDM4EALDH1A1KCNH2GPR119PIK3CA | |
| SCHEMBL1668675 | 0.79 | CNR1 (0.36) | KDM4EALDH1A1KCNH2GPR119PIK3CA | |
| SCHEMBL1671394 | 0.79 | EPHX2 (0.46) | KDM4EALDH1A1KCNH2GPR119PIK3CA | |
| SCHEMBL1668754 | 0.78 | EPHX2 (0.40) | KDM4EALDH1A1KCNH2GPR119PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486033-A1 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY | IRM LLC (BM) | 2012-08-15 | — | — | EP | disclosed |
| WO-2011044001-A1 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY | IRM LLC (BM) | 2011-04-14 | — | — | WO | disclosed |