Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1E | P49674 | 17/20 | 0.52 |
| ▸ | CSNK1D | P48730 | 14/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.41 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18171175 | 0.89 | CSNK1E (0.57) | CSNK1ECSNK1DTAS1R3TAS1R1TAS1R2 | |
| SCHEMBL16728809 | 0.89 | CSNK1E (0.64) | CSNK1ECSNK1D | |
| SCHEMBL16722730 | 0.79 | CSNK1E (0.82) | CSNK1ECSNK1D | |
| SCHEMBL18184044 | 0.78 | CSNK1E (0.69) | CSNK1ECSNK1D | |
| SCHEMBL16722489 | 0.78 | CSNK1E (0.81) | CSNK1ECSNK1D | |
| SCHEMBL18171131 | 0.78 | CSNK1E (0.71) | CSNK1ECSNK1DTAS1R3TAS1R1TAS1R2 | |
| SCHEMBL18171202 | 0.77 | CSNK1E (0.60) | CSNK1ECSNK1DTDP1TAS1R3TAS1R1 | |
| SCHEMBL16699959 | 0.76 | CSNK1E (0.82) | CSNK1ECSNK1D | |
| SCHEMBL16700588 | 0.76 | CSNK1E (0.65) | CSNK1ECSNK1D | |
| SCHEMBL16700825 | 0.75 | CSNK1E (0.60) | CSNK1ECSNK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068784-A1 | SUBSTITUTED 4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRAZINE DERIVATIVES AS CASEIN KINASE 1 D/E INHIBITORS | Bristol-Myers Squibb Company (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073767-A1 | SUBSTITUTED 4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRAZINE DERIVATIVES AS CASEIN KINASE 1 D/E INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-05-21 | — | — | WO | disclosed |