SCHEMBL16728107

SCHEMBL16728107

CN[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O

nearest known ligand 0.69

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
NPY4R P50391 19/20 0.69
NPY1R P25929 11/20 0.69
NPY5R Q15761 10/20 0.69
NPY2R P49146 7/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14702343 0.93 NPY4R (0.61) NPY4RNPY1RNPY5RNPY2R
SCHEMBL11129760 0.90 NPY4R (0.60) NPY4RNPY1RNPY5RNPY2R
SCHEMBL16728103 0.90 NPY4R (0.68) NPY4RNPY1RNPY5RNPY2R
SCHEMBL20902772 0.90 NPY4R (0.68) NPY4RNPY1RNPY5RNPY2R
SCHEMBL12792696 0.89 NPY4R (0.73) NPY4RNPY1RNPY5RNPY2R
SCHEMBL13563464 0.89 NPY4R (0.73) NPY4RNPY1RNPY5RNPY2R
SCHEMBL13563459 0.88 NPY4R (0.77) NPY4RNPY1RNPY5RNPY2R
SCHEMBL15681487 0.88 NPY4R (0.77) NPY4RNPY1RNPY5RNPY2R
SCHEMBL12417393 0.88 NPY4R (0.68) NPY4RNPY1RNPY5RNPY2R
SCHEMBL12417431 0.88 NPY4R (0.68) NPY4RNPY1RNPY5RNPY2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12023378-B2 Covalently linked antigen-antibody conjugates HOFFMANN-LA ROCHE INC. (US) 2024-07-02 US disclosed
US-11273223-B2 Bispecific anti-hapten/anti-blood brain barrier receptor antibodies, complexes thereof and their use as blood brain barrier shuttles HOFFMANN-LA ROCHE INC. (US) 2022-03-15 US disclosed
EP-3068421-B1 SELECTIVE PYY COMPOUNDS AND USES THEREOF NOVO NORDISK AS (DK) 2019-04-17 EP disclosed
US-10246497-B2 Selective PYY compounds and uses thereof NOVO NORDISK A/S (DK) 2019-04-02 US disclosed
WO-2015071355-A1 SELECTIVE PYY COMPOUNDS AND USES THEREOF NOVO NORDISK A/S (DK) 2015-05-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10246497-B2 Selective PYY compounds and uses thereof NPY1R, NPY5R, NPY2R NPY4R 4/4885NPY1R 1/4885NPY5R 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.