Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 13/20 | 0.79 |
| ▸ | GSK3B | P49841 | 13/20 | 0.79 |
| ▸ | FLT3 | P36888 | 11/20 | 0.77 |
| ▸ | JAK2 | O60674 | 7/20 | 0.77 |
| ▸ | SRC | P12931 | 6/20 | 0.77 |
| ▸ | PIK3CG | P48736 | 10/20 | 0.66 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.66 |
| ▸ | PLK1 | P53350 | 6/20 | 0.66 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.66 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.66 |
| ▸ | PRKACA | P17612 | 5/20 | 0.66 |
| ▸ | KDR | P35968 | 4/20 | 0.66 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.66 |
| ▸ | CDK2 | P24941 | 1/20 | 0.66 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.64 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.64 |
| ▸ | SYK | P43405 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16728346 | 1.00 | GSK3A (0.79) | GSK3AGSK3BFLT3JAK2SRC | |
| SCHEMBL17771537 | 0.92 | GSK3A (0.66) | GSK3AGSK3BFLT3JAK2SRC | |
| SCHEMBL9941828 | 0.91 | GSK3A (0.84) | GSK3AGSK3BFLT3JAK2SRC | |
| SCHEMBL17771540 | 0.91 | GSK3A (0.84) | GSK3AGSK3BFLT3JAK2SRC | |
| SCHEMBL17771534 | 0.91 | GSK3A (0.84) | GSK3AGSK3BFLT3JAK2SRC | |
| SCHEMBL24119707 | 0.91 | GSK3A (0.78) | GSK3AGSK3BFLT3JAK2SRC | |
| SCHEMBL21658526 | 0.91 | GSK3A (0.78) | GSK3AGSK3BFLT3JAK2SRC | |
| SCHEMBL23682323 | 0.89 | GSK3A (0.83) | GSK3AGSK3BFLT3JAK2SRC | |
| SCHEMBL18053179 | 0.89 | GSK3A (0.86) | GSK3AGSK3BFLT3JAK2SRC | |
| SCHEMBL18053349 | 0.89 | GSK3A (0.86) | GSK3AGSK3BFLT3JAK2SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210008072-A1 | FORMULATIONS OF AZAINDOLE COMPOUNDS | VERTEX PHARMACEUTICALS INCORPORATED | 2021-01-14 | — | — | US | disclosed |
| US-10640501-B2 | Methods of preparing inhibitors of influenza viruses replication | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2020-05-05 | — | — | US | disclosed |
| EP-3068776-B1 | INHIBITORS OF INFLUENZA VIRUSES REPLICATION | VERTEX PHARMA (US) | 2019-05-29 | — | — | EP | disclosed |
| US-10023569-B2 | Methods of preparing inhibitors of influenza viruses replication | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2018-07-17 | — | — | US | disclosed |
| US-9771361-B2 | Inhibitors of influenza viruses replication | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2017-09-26 | — | — | US | disclosed |
| WO-2015073481-A1 | METHODS OF PREPARING INHIBITORS OF INFLUENZA VIRUSES REPLICATION | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2015-05-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210008072-A1 | FORMULATIONS OF AZAINDOLE COMPOUNDS | H1-0, H1-5, H1-2 | GSK3A 1966/4885GSK3B 2194/4885FLT3 2993/4885 |
| US-10023569-B2 | Methods of preparing inhibitors of influenza viruses replication | ZC3HAV1, ZC3HAV1L, POLR2H | GSK3A 560/4885GSK3B 517/4885FLT3 1019/4885 |
| US-10640501-B2 | Methods of preparing inhibitors of influenza viruses replication | ZC3HAV1, ZC3HAV1L, POLR2H | GSK3A 560/4885GSK3B 517/4885FLT3 1019/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.