SCHEMBL16728622

SCHEMBL16728622

N=Cc1ccc(NC(=O)N2Cc3c(C(N)=O)c(-c4cccc(Cl)c4)nn3C3(CC3)C2)cc1

nearest known ligand 0.48

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CSNK1E P49674 20/20 0.48
CSNK1D P48730 11/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18171195 0.87 CSNK1E (0.59) CSNK1ECSNK1D
SCHEMBL16711377 0.83 CSNK1E (0.60) CSNK1ECSNK1D
SCHEMBL16728874 0.81 CSNK1E (0.46) CSNK1ECSNK1D
SCHEMBL16699649 0.79 CSNK1E (0.56) CSNK1ECSNK1D
SCHEMBL18648757 0.78 CSNK1E (0.66) CSNK1ECSNK1D
SCHEMBL16711374 0.78 CSNK1E (0.45) CSNK1ECSNK1D
SCHEMBL16728885 0.77 CSNK1E (0.68) CSNK1ECSNK1D
SCHEMBL16699150 0.75 CSNK1E (0.47) CSNK1ECSNK1D
SCHEMBL18648758 0.74 CSNK1E (0.68) CSNK1ECSNK1D
SCHEMBL16700222 0.74 CSNK1E (0.76) CSNK1ECSNK1D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015073767-A1 SUBSTITUTED 4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRAZINE DERIVATIVES AS CASEIN KINASE 1 D/E INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2015-05-21 WO disclosed