SCHEMBL16728623

SCHEMBL16728623

NC(=O)c1c(-c2cccc(F)c2)nn2c1CN(N)CC21CC1

nearest known ligand 0.51

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CSNK1E P49674 20/20 0.51
CSNK1D P48730 16/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16699178 0.88 CSNK1E (0.56) CSNK1ECSNK1D
SCHEMBL16709094 0.83 CSNK1E (0.50) CSNK1ECSNK1D
SCHEMBL16709100 0.82 CSNK1E (0.54) CSNK1ECSNK1D
SCHEMBL16709095 0.82 CSNK1E (0.71) CSNK1ECSNK1D
SCHEMBL16700401 0.81 CSNK1E (0.48) CSNK1ECSNK1D
SCHEMBL16728885 0.78 CSNK1E (0.68) CSNK1ECSNK1D
SCHEMBL16699294 0.76 CSNK1E (0.56) CSNK1ECSNK1D
SCHEMBL18171127 0.74 CSNK1E (0.55) CSNK1ECSNK1D
SCHEMBL16700494 0.72 CSNK1E (0.42) CSNK1ECSNK1D
SCHEMBL16699293 0.72 CSNK1E (0.52) CSNK1ECSNK1D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015073767-A1 SUBSTITUTED 4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRAZINE DERIVATIVES AS CASEIN KINASE 1 D/E INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2015-05-21 WO disclosed