Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1E | P49674 | 5/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 4/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | KAT8 | Q9H7Z6 | 5/20 | 0.33 |
| ▸ | KAT6A | Q92794 | 3/20 | 0.33 |
| ▸ | KAT5 | Q92993 | 2/20 | 0.32 |
| ▸ | BTK | Q06187 | 2/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16709033 | 0.91 | CSNK1E (0.48) | CSNK1ECSNK1DTGFBR1BTK | |
| SCHEMBL16728682 | 0.89 | CSNK1E (0.43) | CSNK1ECSNK1DKAT8KAT6AKAT5 | |
| SCHEMBL16728678 | 0.84 | CSNK1E (0.44) | CSNK1ECSNK1DKAT8KAT6ABTK | |
| SCHEMBL16711376 | 0.80 | CSNK1E (0.53) | CSNK1ECSNK1D | |
| SCHEMBL16700141 | 0.80 | CSNK1E (0.45) | CSNK1ECSNK1DTGFBR1BTK | |
| SCHEMBL16711296 | 0.80 | CSNK1E (0.53) | CSNK1ECSNK1D | |
| SCHEMBL16699338 | 0.79 | CSNK1E (0.50) | CSNK1ECSNK1DTGFBR1BTK | |
| SCHEMBL16709028 | 0.79 | CSNK1E (0.53) | CSNK1ECSNK1DBTK | |
| SCHEMBL16709026 | 0.79 | CSNK1E (0.53) | CSNK1ECSNK1DBTK | |
| SCHEMBL16709061 | 0.79 | CSNK1E (0.53) | CSNK1ECSNK1DKAT8KAT6ABTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015073767-A1 | SUBSTITUTED 4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRAZINE DERIVATIVES AS CASEIN KINASE 1 D/E INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-05-21 | — | — | WO | disclosed |