Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 20/20 | 0.64 |
| ▸ | HCRTR2 | O43614 | 20/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1671111 | 0.86 | HCRTR1 (0.68) | HCRTR1HCRTR2 | |
| SCHEMBL1673098 | 0.84 | HCRTR1 (0.69) | HCRTR1HCRTR2 | |
| SCHEMBL1671464 | 0.84 | HCRTR1 (0.69) | HCRTR1HCRTR2 | |
| SCHEMBL1671886 | 0.84 | HCRTR1 (0.69) | HCRTR1HCRTR2 | |
| SCHEMBL1671483 | 0.84 | HCRTR1 (0.69) | HCRTR1HCRTR2 | |
| SCHEMBL1672003 | 0.83 | HCRTR1 (0.70) | HCRTR1HCRTR2 | |
| SCHEMBL1673008 | 0.81 | HCRTR1 (0.64) | HCRTR1HCRTR2 | |
| SCHEMBL1671118 | 0.80 | HCRTR1 (0.67) | HCRTR1HCRTR2 | |
| SCHEMBL1671485 | 0.80 | HCRTR1 (0.54) | HCRTR1HCRTR2 | |
| SCHEMBL1671274 | 0.80 | HCRTR1 (0.67) | HCRTR1HCRTR2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012145581-A1 | DISUBSTITUTED OCTAHY-DROPYRROLO [3,4-C] PYRROLES AS OREXIN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2012-10-26 | — | — | WO | disclosed |
| EP-2491038-A1 | DISUBSTITUTED OCTAHY - DROPYRROLO [3,4-C]PYRROLES AS OREXIN RECEPTOR MODULATORS | Janssen Pharmaceutica N.V. (BE) | 2012-08-29 | — | — | EP | disclosed |
| WO-2011050198-A1 | DISUBSTITUTED OCTAHY - DROPYRROLO [3,4-C] PYRROLES AS OREXIN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2011-04-28 | — | — | WO | disclosed |