Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18028138 | 0.91 | MAPT (0.45) | MAPTKDM4EL3MBTL1ALOX15ALDH1A1 | |
| SCHEMBL16730425 | 0.90 | MAPT (0.44) | MAPTKDM4EL3MBTL1ALOX15ALDH1A1 | |
| SCHEMBL16730290 | 0.82 | SMN1; SMN2 (0.42) | MAPTKDM4EL3MBTL1ALOX15ALDH1A1 | |
| SCHEMBL16730429 | 0.80 | MAPT (0.49) | MAPTKDM4EL3MBTL1ALOX15ALDH1A1 | |
| SCHEMBL18383369 | 0.76 | CNR1 (0.62) | MAPTKDM4EL3MBTL1ALDH1A1USP2 | |
| SCHEMBL16730277 | 0.75 | NPC1 (0.57) | MAPTKDM4EL3MBTL1ALOX15ALDH1A1 | |
| SCHEMBL16730286 | 0.75 | MAPT (0.46) | MAPTKDM4EL3MBTL1ALOX15ALDH1A1 | |
| SCHEMBL17713154 | 0.74 | CNR1 (0.49) | MAPTKDM4EL3MBTL1ALOX15ALDH1A1 | |
| SCHEMBL16730279 | 0.74 | NPC1 (0.53) | MAPTKDM4EL3MBTL1ALOX15ALDH1A1 | |
| SCHEMBL18028126 | 0.73 | MAPT (0.49) | MAPTALDH1A1USP2SMN1; SMN2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3072892-A1 | PYRIDINE DERIVATIVE AND MEDICAL USE THEREOF | Chengdu Easton Biopharmaceuticals Co., Ltd. (CN) | 2016-09-28 | — | — | EP | disclosed |
| WO-2015070809-A1 | PYRIDINE DERIVATIVE AND MEDICAL USE THEREOF | 成都苑东药业有限公司 | 2015-05-21 | — | — | WO | disclosed |