Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.50 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.50 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.50 |
| ▸ | CSNK1E | P49674 | 14/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 9/20 | 0.41 |
| ▸ | RIPK2 | O43353 | 4/20 | 0.40 |
| ▸ | LCK | P06239 | 3/20 | 0.39 |
| ▸ | KDR | P35968 | 3/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16722719 | 0.88 | TLR9 (0.54) | TLR9TLR8TLR7CSNK1ECSNK1D | |
| SCHEMBL16700106 | 0.88 | TLR9 (0.51) | TLR9TLR8TLR7CSNK1ECSNK1D | |
| SCHEMBL16699578 | 0.85 | TLR9 (0.49) | TLR9TLR8TLR7CSNK1ECSNK1D | |
| SCHEMBL16722751 | 0.82 | TLR9 (0.47) | TLR9TLR8TLR7CSNK1ECSNK1D | |
| SCHEMBL16722633 | 0.81 | TLR9 (0.45) | TLR9TLR8TLR7CSNK1ECSNK1D | |
| SCHEMBL16699002 | 0.81 | CSNK1E (0.52) | TLR9TLR8TLR7CSNK1ECSNK1D | |
| SCHEMBL16722700 | 0.80 | TLR9 (0.46) | TLR9TLR8TLR7CSNK1ECSNK1D | |
| SCHEMBL16722695 | 0.79 | CSNK1E (0.57) | TLR9TLR8TLR7CSNK1ECSNK1D | |
| SCHEMBL16728803 | 0.79 | TLR9 (0.46) | TLR9TLR8TLR7CSNK1ECSNK1D | |
| SCHEMBL16722416 | 0.79 | TLR9 (0.54) | TLR9TLR8TLR7CSNK1ECSNK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015073763-A1 | SUBSTITUTED 4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRAZINE DERIVATIVES AS CASEIN KINASE 1 D/E INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-05-21 | — | — | WO | disclosed |