Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1E | P49674 | 16/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 13/20 | 0.36 |
| ▸ | CTSS | P25774 | 2/20 | 0.34 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16709112 | 0.96 | CSNK1E (0.40) | CSNK1ECSNK1DCTSSRIPK2 | |
| SCHEMBL16709115 | 0.91 | CSNK1E (0.37) | CSNK1ECSNK1DCTSS | |
| SCHEMBL16709113 | 0.89 | CSNK1E (0.44) | CSNK1ECSNK1DRIPK2 | |
| SCHEMBL16699346 | 0.88 | CSNK1E (0.39) | CSNK1ECSNK1D | |
| SCHEMBL16709129 | 0.85 | CSNK1E (0.44) | CSNK1ECSNK1DRIPK2 | |
| SCHEMBL16700632 | 0.83 | CSNK1E (0.36) | CSNK1ECSNK1D | |
| SCHEMBL16700635 | 0.83 | CSNK1E (0.36) | CSNK1ECSNK1D | |
| SCHEMBL16700636 | 0.83 | CSNK1E (0.36) | CSNK1ECSNK1DTGFBR1TGFBR2 | |
| SCHEMBL16709109 | 0.82 | MEN1 (0.35) | CSNK1ECSNK1D | |
| SCHEMBL16709123 | 0.80 | KAT5 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015073763-A1 | SUBSTITUTED 4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRAZINE DERIVATIVES AS CASEIN KINASE 1 D/E INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-05-21 | — | — | WO | disclosed |