SCHEMBL16730833

SCHEMBL16730833

COC1CC(NC(=O)N2CCn3nc(-c4ccc(F)c(Cl)c4)c(C(N)=O)c3C2)C1

nearest known ligand 0.59

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CSNK1E P49674 20/20 0.59
CSNK1D P48730 13/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16711372 1.00 CSNK1E (0.59) CSNK1ECSNK1D
SCHEMBL17527268 1.00 CSNK1E (0.59) CSNK1ECSNK1D
SCHEMBL16711381 1.00 CSNK1E (0.59) CSNK1ECSNK1D
SCHEMBL17527241 0.93 CSNK1E (0.57) CSNK1ECSNK1D
SCHEMBL16711266 0.93 CSNK1E (0.57) CSNK1ECSNK1D
SCHEMBL16701071 0.91 CSNK1E (0.62) CSNK1ECSNK1D
SCHEMBL16711497 0.90 CSNK1E (0.57) CSNK1ECSNK1D
SCHEMBL16700869 0.90 CSNK1E (0.57) CSNK1ECSNK1D
SCHEMBL16700870 0.90 CSNK1E (0.57) CSNK1ECSNK1D
SCHEMBL21131139 0.90 CSNK1E (0.57) CSNK1ECSNK1D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015073763-A1 SUBSTITUTED 4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRAZINE DERIVATIVES AS CASEIN KINASE 1 D/E INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2015-05-21 WO disclosed