Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 15/20 | 0.65 |
| ▸ | HCRTR1 | O43613 | 12/20 | 0.65 |
| ▸ | NPC1 | O15118 | 5/20 | 0.45 |
| ▸ | RAB9A | P51151 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1672099 | 0.79 | HCRTR2 (1.00) | HCRTR2HCRTR1 | |
| SCHEMBL1673171 | 0.76 | HCRTR2 (0.75) | HCRTR2HCRTR1 | |
| SCHEMBL1671903 | 0.71 | HCRTR2 (1.00) | HCRTR2HCRTR1 | |
| SCHEMBL1673018 | 0.69 | NPC1 (0.60) | HCRTR2HCRTR1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4319929 | 0.67 | HCRTR1 (1.00) | HCRTR2HCRTR1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10219134 | 0.67 | NPC1 (0.60) | HCRTR2HCRTR1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10271881 | 0.67 | NPC1 (0.60) | HCRTR2HCRTR1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11909230 | 0.64 | HCRTR1 (0.68) | HCRTR2HCRTR1NPC1RAB9A | |
| SCHEMBL14843865 | 0.64 | HCRTR2 (0.72) | HCRTR2HCRTR1NPC1RAB9AMAPT | |
| SCHEMBL10222030 | 0.64 | NPC1 (0.56) | HCRTR2HCRTR1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2491038-A1 | DISUBSTITUTED OCTAHY - DROPYRROLO [3,4-C]PYRROLES AS OREXIN RECEPTOR MODULATORS | Janssen Pharmaceutica N.V. (BE) | 2012-08-29 | — | — | EP | claimed |
| WO-2011050198-A1 | DISUBSTITUTED OCTAHY - DROPYRROLO [3,4-C] PYRROLES AS OREXIN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2011-04-28 | — | — | WO | claimed |