Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 5/20 | 0.59 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.59 |
| ▸ | PAK1 | Q13153 | 3/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.50 |
| ▸ | PLK4 | O00444 | 2/20 | 0.50 |
| ▸ | PAK4 | O96013 | 2/20 | 0.50 |
| ▸ | PDE4A | P27815 | 2/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 3/20 | 0.42 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL166457 | 0.83 | JAK2 (0.49) | AURKAAURKBPAK1NTRK1PLK4 | |
| SCHEMBL166273 | 0.78 | PAK1 (0.51) | AURKAAURKBPAK1NTRK1PLK4 | |
| SCHEMBL164643 | 0.78 | AURKA (0.61) | AURKAAURKBPAK1NTRK1PAK4 | |
| SCHEMBL24175120 | 0.78 | PAK1 (0.59) | AURKAAURKBPAK1NTRK1PAK4 | |
| SCHEMBL166132 | 0.78 | JAK2 (0.70) | AURKAAURKBPAK1NTRK1PLK4 | |
| SCHEMBL256488 | 0.78 | JAK2 (0.70) | AURKAAURKBPAK1NTRK1PLK4 | |
| SCHEMBL177656 | 0.77 | PAK1 (0.49) | AURKAAURKBPAK1NTRK1PLK4 | |
| SCHEMBL14606095 | 0.76 | PAK1 (0.60) | AURKAAURKBPAK1NTRK1PLK4 | |
| SCHEMBL23889520 | 0.76 | PAK1 (0.63) | AURKAAURKBPAK1PAK4JAK2 | |
| SCHEMBL30147226 | 0.76 | PAK1 (0.60) | AURKAAURKBPAK1NTRK1PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611812-A1 | THIENOPYRIDINE AND THIENOPYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF | Ambit Biosciences Corporation (US) | 2013-07-10 | — | — | EP | claimed |
| WO-2012030894-A1 | THIENOPYRIDINE AND THIENOPYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2012-03-08 | — | — | WO | claimed |
| EP-2611812-A1 | THIENOPYRIDINE AND THIENOPYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF | Ambit Biosciences Corporation (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012030894-A1 | THIENOPYRIDINE AND THIENOPYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2012-03-08 | — | — | WO | disclosed |