Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 20/20 | 0.65 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16743159 | 0.93 | SYK (0.71) | SYKAURKBKCNH2 | |
| SCHEMBL16743161 | 0.89 | SYK (0.65) | SYKKCNH2 | |
| SCHEMBL16743167 | 0.86 | SYK (0.67) | SYKAURKBKCNH2 | |
| SCHEMBL16743166 | 0.85 | SYK (0.73) | SYKAURKBKCNH2 | |
| SCHEMBL16743175 | 0.85 | SYK (0.73) | SYKAURKBKCNH2 | |
| SCHEMBL16743160 | 0.85 | SYK (0.68) | SYKAURKBKCNH2 | |
| SCHEMBL16743176 | 0.85 | SYK (0.68) | SYKAURKBKCNH2 | |
| SCHEMBL16743209 | 0.84 | SYK (0.70) | SYKAURKBKCNH2 | |
| SCHEMBL16743258 | 0.81 | SYK (0.71) | SYKAURKBKCNH2 | |
| SCHEMBL16253433 | 0.81 | SYK (0.70) | SYKAURKBKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9040530-B2 | 1,2,4-triazine-6-carboxamide kinase inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2015-05-26 | — | — | US | disclosed |
| US-9040530-B2 | 1,2,4-triazine-6-carboxamide kinase inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2015-05-26 | — | — | US | disclosed |