Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 20/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.56 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16743172 | 0.87 | SYK (0.60) | SYKKCNH2 | |
| SCHEMBL14961965 | 0.86 | SYK (0.57) | SYKKCNH2EML4ALK | |
| SCHEMBL23080962 | 0.82 | BTK (0.60) | SYK | |
| SCHEMBL20540648 | 0.81 | BTK (0.66) | — | |
| SCHEMBL18296321 | 0.81 | BTK (0.66) | — | |
| SCHEMBL16743176 | 0.79 | SYK (0.68) | SYKKCNH2AURKB | |
| SCHEMBL16743160 | 0.79 | SYK (0.68) | SYKKCNH2AURKB | |
| SCHEMBL16743186 | 0.79 | SYK (0.71) | SYKKCNH2AURKB | |
| SCHEMBL16743230 | 0.78 | SYK (0.63) | SYKKCNH2 | |
| SCHEMBL16743191 | 0.78 | SYK (0.76) | SYKKCNH2EML4ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9040530-B2 | 1,2,4-triazine-6-carboxamide kinase inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2015-05-26 | — | — | US | disclosed |
| US-9040530-B2 | 1,2,4-triazine-6-carboxamide kinase inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2015-05-26 | — | — | US | disclosed |