Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 20/20 | 0.44 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16743271 | 0.90 | SYK (0.54) | SYK | |
| SCHEMBL16743152 | 0.88 | SYK (0.47) | SYKZAP70 | |
| SCHEMBL16743267 | 0.86 | SYK (0.44) | SYKZAP70 | |
| SCHEMBL16743304 | 0.85 | SYK (0.49) | SYKZAP70 | |
| SCHEMBL16743315 | 0.84 | SYK (0.44) | SYKZAP70 | |
| SCHEMBL16743355 | 0.83 | SYK (0.43) | SYKZAP70 | |
| SCHEMBL14955275 | 0.82 | SYK (0.41) | SYKZAP70 | |
| SCHEMBL14955273 | 0.82 | SYK (0.41) | SYKZAP70 | |
| SCHEMBL16743302 | 0.82 | SYK (0.51) | SYK | |
| SCHEMBL16743300 | 0.81 | SYK (0.42) | SYKZAP70 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9040530-B2 | 1,2,4-triazine-6-carboxamide kinase inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2015-05-26 | — | — | US | disclosed |
| US-9040530-B2 | 1,2,4-triazine-6-carboxamide kinase inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2015-05-26 | — | — | US | disclosed |