Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 20/20 | 0.59 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16743333 | 0.90 | SYK (0.58) | SYKKCNH2 | |
| SCHEMBL16743336 | 0.88 | SYK (0.57) | SYKKCNH2 | |
| SCHEMBL16743375 | 0.88 | SYK (0.56) | SYKKCNH2 | |
| SCHEMBL16743325 | 0.87 | SYK (0.57) | SYKKCNH2 | |
| SCHEMBL16743369 | 0.85 | SYK (0.53) | SYKKCNH2AURKB | |
| SCHEMBL14956223 | 0.84 | IRAK4 (0.58) | SYKMAPK3MAPK1KCNH2AURKB | |
| SCHEMBL16743352 | 0.84 | SYK (0.52) | SYKKCNH2AURKB | |
| SCHEMBL16743324 | 0.84 | SYK (0.54) | SYKKCNH2 | |
| SCHEMBL16743318 | 0.84 | SYK (0.60) | SYKKCNH2AURKB | |
| SCHEMBL16743359 | 0.83 | SYK (0.51) | SYKKCNH2AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9040530-B2 | 1,2,4-triazine-6-carboxamide kinase inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2015-05-26 | — | — | US | disclosed |
| US-9040530-B2 | 1,2,4-triazine-6-carboxamide kinase inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2015-05-26 | — | — | US | disclosed |