Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 3/20 | 0.42 |
| ▸ | JAK3 | P52333 | 3/20 | 0.42 |
| ▸ | BTK | Q06187 | 3/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.41 |
| ▸ | SYK | P43405 | 14/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16743337 | 0.87 | LCK (0.42) | LCKJAK3BTKIRAK4SYK | |
| SCHEMBL14955909 | 0.84 | BTK (0.42) | LCKJAK3BTKIRAK4SYK | |
| SCHEMBL14956216 | 0.84 | BTK (0.53) | LCKJAK3BTKIRAK4SYK | |
| SCHEMBL14955908 | 0.84 | BTK (0.42) | LCKJAK3BTKIRAK4SYK | |
| SCHEMBL14956218 | 0.84 | BTK (0.53) | LCKJAK3BTKIRAK4SYK | |
| SCHEMBL2728928 | 0.81 | BTK (0.39) | LCKJAK3BTKIRAK4SYK | |
| SCHEMBL2728921 | 0.81 | BTK (0.39) | LCKJAK3BTKIRAK4SYK | |
| SCHEMBL16743355 | 0.81 | SYK (0.43) | LCKJAK3BTKSYKAURKB | |
| SCHEMBL14955647 | 0.80 | BTK (0.55) | LCKJAK3BTKIRAK4SYK | |
| SCHEMBL14955649 | 0.80 | BTK (0.55) | LCKJAK3BTKIRAK4SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9040530-B2 | 1,2,4-triazine-6-carboxamide kinase inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2015-05-26 | — | — | US | disclosed |
| US-9040530-B2 | 1,2,4-triazine-6-carboxamide kinase inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2015-05-26 | — | — | US | disclosed |