Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 18/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15935592 | 0.85 | SYK (0.65) | SYKAURKB | |
| SCHEMBL18296318 | 0.79 | BTK (0.62) | LCKJAK3BTK | |
| SCHEMBL23080770 | 0.79 | JAK3 (0.48) | SYKAURKBLCKJAK3BTK | |
| SCHEMBL16743216 | 0.78 | SYK (0.56) | SYKAURKBBTK | |
| SCHEMBL5025898 | 0.77 | SYK (0.46) | SYKLCKJAK3BTK | |
| SCHEMBL23080760 | 0.77 | JAK3 (0.45) | SYKAURKBLCKJAK3BTK | |
| SCHEMBL5026842 | 0.77 | SYK (0.49) | SYKLCKJAK3BTK | |
| SCHEMBL16743259 | 0.76 | SYK (0.63) | SYKAURKBLCKJAK3 | |
| SCHEMBL23080862 | 0.76 | JAK3 (0.52) | SYKAURKBLCKJAK3BTK | |
| SCHEMBL10250525 | 0.75 | FER (0.40) | SYKLCKJAK3BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9040530-B2 | 1,2,4-triazine-6-carboxamide kinase inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2015-05-26 | — | — | US | disclosed |
| US-9040530-B2 | 1,2,4-triazine-6-carboxamide kinase inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2015-05-26 | — | — | US | disclosed |